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學術論文

[1] Yinsheng Zhang*, A new method for the preparation of deuterated amines using D2O as a deuterium source and its application in the syntheses of deuterated pharmaceuticals. 34th International North American Chapter Symposium of IIS, Morristown, USA, 17th – 18th October 2024.

 

[2] Dinglong Cai, Chenggu Zhu, Gang Li*, et al. The production of C-14 source material and the development of C-14 technologies platform. 34th International North American Chapter Symposium of IIS, Morristown, USA, 17th – 18th October 2024.

 

[3] Yifei He, Yuandong Zheng, Chenggu Zhu, Peng Lei, Jinghua Yu, Chongzhuang Tang, Hao Chen*, Xingxing Diao*, Radioactive ADME Demonstrates ARV-110’s High Druggability Despite Low Oral Bioavailability. J. Med. Chem. 2024, 67, 16, 14277–14291.

 

[4] Study of the mass balance, biotransformation and safety of [ 14C]SHR8554, a novel μ-opioid receptor injection, in healthy Chinese subjects. Front Pharmacol. 2023 Sep 14:14:1231102

 

[5]Ling Senyan, Fang Ningjing, Cai Dinglong, Li Gang. Research on Three Methods for the Synthesis of 14C-Labeled Cyanoacetic Acid. The 8th National Conference on Isotope Preparation and Application (Wuhan, 2023).

 

[6] Li Zhang, Yinsheng Zhang*, et al. Discovery, optimization and biological evaluation of novel HBsAg production inhibitors.. European Journal of Medicinal Chemistry 2023, 256:115387.  

 

[7] Zhu Chenggu, Cai Dinglong, Yan Shengwang, Fang Ningjing, Xue Kai, Li Gang. Application of [14C]Carbon Monoxide in Radioisotope-Labeled Synthesis. Journal of Isotopes, 2022.

 

[8] Yinsheng Zhang, An Efficient and Facile Synthesis of Deuterium-Labeled D-Glycerolphosphocholine and 2,3-Dilinoleoyl-sn-glycero-3-phosphocholine. ChemistrySelect  2020, 5, 11590-11595.

 

[9] Zhang Yinsheng, Synthesis of deuterium-labeled nelarabine and its active ingredient, ara-?G. Journal of Radioanalytical and Nuclear Chemistry 2020, 325(1), 47-55.

 

[10] Zhang, Yinsheng, Synthesis and biological evaluation of deuterated sofosbuvir analogs as HCV NS5B inhibitors with enhanced pharmacokinetic properties. J. Label. Compd. Radiopharm. 2019, 62(5), 215-229.

 

[11] Gai, Kuo; Liu, Baomin; Zhang, Yinsheng*, Identification of unexpected unlabeled N,N-dimethylamide formation in the synthesis of deuterated fragment of ribociclib by a HATU-?mediated coupling reaction. J. Label. Compd. Radiopharm. 2019, 62(2), 62-66.

 

[12] Liu Weijun, Zhu Chenggu, Wang Wei, Yan Shengwang, Fei Jing, Li Gang. Synthesis of Carbon -13 and Carbon 14 Isotope Labeled Taltirelin. IIS 29th North American Chapter Symposium, 2016.

 

[13] Zhu Chenggu, Yan Shengwang, Fei Jing, Li Gang. A New Method for Synthesising Isotope Labeled Carnitine. IIS 26th Northeast US Chapter Symposium, 2015.

 

[14] Zhu Chenggu, Cai Dinglong, Li Gang. Calculation Method of Isotope Peak Abundance Distribution of Organic Compounds. Annual Conference of China Isotope Preparation and Application, 2015.

 

[15] Zhu Chenggu, Yang Shaozu, Yan Shengwang, Fang Ningjing, Cai Dinglong, Li Gang. Synthesis of Gemcitabine-13C,15N2 and Its Metabolites. Journal of Isotopes, 2014, 27(02), 82-86.

 

[16] Zhang, Yinsheng, Preparation of tritium-labeled PF-622, a novel fatty acid amide hydrolase inhibitor. J. Label. Compd. Radiopharm. 2017, 60(13), 608-615.

 

[17] Zhu Chenggu, Yan Shengwang, Fang Ningjing, Yang Shaozu, Li Gang. Synthesis of N,N-Diisopropyl-[(1-13C)Ethyl]Amine. The 10th Annual Conference of China Nuclear Society "Three Nuclei" Forum, 2013, pp. 175-17

 

[18] Wang Wei, Zhu Chenggu, Li Gang. First Synthesis of Carbon 13 and Carbon 14 Isotope Labeled Honokiol. IIS 26th Northeast US Chapter Symposium, 2011.

 

[19] Li Gang, Yang Shaozu, Wang Wei, Chen Saibo, Zhu Chenggu, Wang Feng. A New Method to Prepare Radioactive and Stable Isotope Labeled Carboxylic Acids. IIS 25th Northeast US Chapter Symposium, 2010.